Can periodontitis or other inflammatory processes of the oral cavity contribute to systemic conditions such as atherosclerosis or diabetes, or negatively influence their course?

This 3D animation Oral Health and General Health - the latest module of the Cell-to-Cell Communication series - addresses these issues by visualizing the highly complex intercellular interactions and signaling pathways. Periodontal pathogens are invasive and can spread throughout the body via the bloodstream. Locally produced pro-inflammatory mediators can also shed into the circulation. This new film features an interdisciplinary topic, and in this context, special attention is given to diseases such as atherosclerosis and type 2 diabetes. This sophisticated HD video animation makes the relevant information and latest insights accessible to a wider audience.

Outline
• Dissemination of bacteria in periodontitis
• Impact of periodontitis on the cardiovascular system: Atherosclerosis
• Effect of periodontitis on glucose metabolism: Type 2 diabetes
• Dental treatment

DVD 1: Expert Version (Length: 17 minutes)
DVD 2: Public Version (Length:14 minutes)


In This Film
Main Cast:
Periodontal Biofilm, Endothelial Cells, Monocytes, Macrophages, T-Lymphocytes, Thrombocytes, Insulin, Glucose, Advanced Glycation Endproducts (AGEs)

Also Starring:
Toll-Like Receptor 2 (TLR2), Toll-Like Receptor 4 (TLR4), Monocyte Chemotactic Protein (MCP-1), Vascular Cell Adhesion Molecules (VCAMs), Matrix Metalloproteinases (MMPs), C-Reactive Protein (CRP), Tumor Necrosis Factor Alpha (TNF -α), Interleukin 6 (IL-6), Receptor for Advanced Glycation Endproducts (RAGE)

Project/Expert Team

Authors:
Prof. Dr. Dr. Søren Jepsen, Prof. Dr. Mariano Sanz, PD Dr. Dr. Bernd Stadlinger, Prof. Dr. Hendrik Terheyden

Advisory Board:
Prof. Dr.Iain Chapple, Prof. Dr. Robert Genco, Prof. Dr. Evanthia Lalla, Prof. Dr. Shinya Murakami

Scanning Electron Microscopic Images:
Nicole Ottawa & Oliver Meckes, eye of science

Jepsen, Søren / Sanz, Mariano / Stadlinger, Bernd / Terheyden, Hendrik Cell-to-Cell Communication: Oral Health and General Health (Expert Version)

Jepsen, Søren/Sanz, Mariano/Sta... Kommunikation der Zellen: Orale und Systemische Gesundheit Cell-to-Cell Communication, Volume 4 1. Auflage 2016 Artikelnr.: 5670 98.00 € Jepsen, Søren / Sanz, Mariano / Stadlinger, Bernd / Terheyden, Hendrik Kommunikation der Zellen: Orale und Systemische Gesundheit Können eine Parodontitis oder andere entzündliche Prozesse der Mundhöhle zur Entstehung kardiovaskulärer oder systemischer Erkrankungen wie Atherosklerose und Diabetes beitragen oder ihren Verlauf negativ beeinflussen? Mit dem computeranimierten 3D Wissenschaftsfilm Orale und systemische Gesundheit - dem vierten Modul aus der Reihe Kommunikation der Zellen - wird ein hochaktuelles medizinisches Thema visualisiert. Erstmals werden biologische Prozesse auch außerhalb der Mundhöhle beschrieben, de[...]	Berglundh, Tord/Jepsen, Søren/S... Cell-to-Cell Communication: Peri-implantitis and its Prevention Cell-to-Cell Communication, Volume 6 1st Edition 2019 Artikelnr.: 5710 98.00 € Berglundh, Tord / Jepsen, Søren / Stadlinger, Bernd / Terheyden, Hendrik Cell-to-Cell Communication: Peri-implantitis and its Prevention Just like with natural teeth, if the plaque biofilm is allowed to accumulate at inflammation of the surrounding soft tissue - peri-implant mucositis - occurs which can subsequently develop into peri-implantitis, characterized by peri-implant bone destruction and even implant loss. The new 3D movie Peri-implantitis and its Prevention, the sixth episode of the cutting edge HD video animation series on Cell-to-Cell Communication describes the processes from peri-implant health to mucositis, the tr[...]
Stadlinger, Bernd/Terheyden, He... Cell-to-Cell Communication: Guided Bone Regeneration Cell-to-Cell Communication, Volume 5 1st Edition 2016 Artikelnr.: 5620 98.00 € Stadlinger, Bernd / Terheyden, Hendrik Cell-to-Cell Communication: Guided Bone Regeneration The 3D animation Guided Bone Regeneration is the latest module of the Cell-to-Cell Communication series. To the extent that the details of the highly complex intercellular processes are amenable to presentation by computer animation, the present film, with its stunning didactical, dramaturgical, and visual appeal, successfully conveys the essentials of cell-to-cell communication, visualizing the invisible yet fascinating world of signals and signaling within the human body. Outline • The hemost[...]	Stadlinger, Bernd/Terheyden, He... Cell-to-Cell Communication Periodontal Regeneration Cell-to-Cell Communication, Volume 3 2nd Edition 2015 Artikelnr.: 5792 98.00 € Stadlinger, Bernd / Terheyden, Hendrik Cell-to-Cell Communication Periodontal Regeneration Unlike bone, which undergoes remodeling by resorption followed by bone apposition, teeth are not subject to physiological remodeling. They are remarkably resistant to physiological remodeling processes. The reason for this is found in the periodontium and cementum. The mechanisms that take effect in this area and the effectiveness of the periodontal system - consisting of gingiva, alveolar bone, periodontium and cementum - after injuries will be visualized in the new scientific 3D film, "Periodo[...]
Stadlinger, Bernd/Terheyden, He... Cell-to-Cell Communication Inflammatory Reactions Cell-to-Cell Communication, Volume 2 2nd Edition 2013 Artikelnr.: 5791 98.00 € Stadlinger, Bernd / Terheyden, Hendrik Cell-to-Cell Communication Inflammatory Reactions Visualizing the invisible while experiencing a fascination with science is the great challenge that Cell-to-Cell Communication, representing an all-new genre, has set out to meet. A spectacularly sophisticated computer animation in HD quality depicts the highly complex processes of intercellular interaction during an inflammatory periodontal reaction complete with the messenger molecules implicated. The various cell types constitute the main cast of the film, using a finely tuned communication p[...]	Stadlinger, Bernd/Terheyden, He... Cell-to-Cell Communication Osseointegration Cell-to-Cell Communication, Volume 1 2nd Revised Edition 2016 Artikelnr.: 5690 98.00 € Stadlinger, Bernd / Terheyden, Hendrik Cell-to-Cell Communication Osseointegration The invisible becomes visible and holds both challenge and fascination. The cellular-level biological processes that underlie osseointegration are visualized based on the cell types and messengers implicated, representing the current state of our knowledge. Complex biodynamic processes are showcased dramatically and didactically to support the transfer of knowledge in training and education. Module 1, Cell-To-Cell Communication - Osseointegration, ushers in an Initiative for Excellence entitled[...]
Yoshie, Hiromasa At the Forefront Illustrated Topics in Dental Research and Clinical Practice 1st Edition 2012 Artikelnr.: 19771 98.00 € Yoshie, Hiromasa At the Forefront Illustrated Topics in Dental Research and Clinical Practice This volume brings together articles on the topics of bioscience and clinical science, punctuated with striking illustrations, that have been recently published in the Japanese journal The Quintessence. The first half of the book addresses important oral and systemic health topics such as diagnosis of periodontal disease using blood and saliva testing; periodontal tissue, salivary gland, and tooth regeneration; tissue-engineered bone; correlation of periodontal disease with cardiovascular dise[...]