The fifth edition of this popular textbook includes a new clinical section and additional illustrations. The authors create a refreshing self-study approach using direct langua and helpful metaphors. Self tests are strategically placed f the board examinations, or as a refresher for busy practitioners who want to stay abreast of this rapidly advancing field. Clearly written, with numerous illustration and tables.

Contents

Part I	Acute Inflammatory Process
	Preface	vii
	Introduction	ix
	Abbreviations	xi
1	Vascular Response to Injury	3
	Quick Review	3
	The vascular events	6
	Exudation, transudation, and edema	12
	The lymphatic system	16
	Postscript	17
2	Chemical Mediators of the Vascular Response	19
	Histamine	28
	Serotonin	29
	Plasma proteases	21
	The kinin system	21
	The fibrinolytic system	22
	Advice from some old friends	24
	The complement system	25
	Eicosanoids	32
	Platelet activating factor	35
	Nitric oxide	35
	Neuropeptides	35
	Other mediators	37
	Pain associated with acute inflammation	38
3	The Blood Leukocytes	41
	The cells involved	41
	The individual leukocytes	42
	The mononuclear-phagocytic system	62
4	Systemic Manifestations of Inflammation	71
Part II	Immunity
5	The Immune System	77
	The opponents	78
	The defenders	78
	Antigen-presenting cells	87
	The system	83
	Immunoglobulins	91
	General battle plan	97
	Duration of antibody response	99
6	Hypersensitivity Reactions	111
	Type I - immediate-type hypersensitivity	111
	Type II - Immune cytotoxic reactions	111
	Type III - Immune complex hypersensitivity	115
	Type IV - Delayed-type hypersensitivity	117
	Immunologic tolerance	125
	Immunodeficiency	125
7	Chronic Inflammatory Processes	129
	General considerations	130
	Causes of chronic inflammation	134
	Factors contributing to chronicity	136
	Maintenance of chronicity	136
	Other cells involved	139
	Tissue damage	140
	Chemical mediators	140
	Essential elements	140
	Granulomatous inflammation	141
	Control of inflammation	142
Part III	Repair of Host Tissues
8	Healing	149
	Resolution vs repair	149
	Regeneration	150
	Fibrous repair	151
	Cell-matrix interaction	154
	Cell-cell interaction	155
	The role cells play in wound healing	155
	What is organization?	159
	Epithelialization	160
	Strength of healing wounds	161
	Remodelling of wounds	161
	Local and systematic factors influencing healing	165
Part IV	Application of Basic Principles
9	Clinical Connections	171
	Inflammation of the tooth pulp (pulpitis)	172
	Inflammatory lesions of the periapical tissues	185
	Acute pyogenic osteomyelitis of the jaws	196
	Chronic osteomyelitis of the jaws	197
	Cellulitis	197
	Periodontal disease	198
	Acquired immunodeficiency syndrome	203
	Answers to Self-Test and Charts	211
Index		225