Part I | Acute Inflammatory Process | |
| Preface | vii |
| Introduction | ix |
| Abbreviations | xi |
1 | Vascular Response to Injury | 3 |
| Quick Review | 3 |
| The vascular events | 6 |
| Exudation, transudation, and edema | 12 |
| The lymphatic system | 16 |
| Postscript | 17 |
2 | Chemical Mediators of the Vascular Response | 19 |
| Histamine | 28 |
| Serotonin | 29 |
| Plasma proteases | 21 |
| The kinin system | 21 |
| The fibrinolytic system | 22 |
| Advice from some old friends | 24 |
| The complement system | 25 |
| Eicosanoids | 32 |
| Platelet activating factor | 35 |
| Nitric oxide | 35 |
| Neuropeptides | 35 |
| Other mediators | 37 |
| Pain associated with acute inflammation | 38 |
3 | The Blood Leukocytes | 41 |
| The cells involved | 41 |
| The individual leukocytes | 42 |
| The mononuclear-phagocytic system | 62 |
4 | Systemic Manifestations of Inflammation | 71 |
Part II | Immunity | |
5 | The Immune System | 77 |
| The opponents | 78 |
| The defenders | 78 |
| Antigen-presenting cells | 87 |
| The system | 83 |
| Immunoglobulins | 91 |
| General battle plan | 97 |
| Duration of antibody response | 99 |
6 | Hypersensitivity Reactions | 111 |
| Type I - immediate-type hypersensitivity | 111 |
| Type II - Immune cytotoxic reactions | 111 |
| Type III - Immune complex hypersensitivity | 115 |
| Type IV - Delayed-type hypersensitivity | 117 |
| Immunologic tolerance | 125 |
| Immunodeficiency | 125 |
7 | Chronic Inflammatory Processes | 129 |
| General considerations | 130 |
| Causes of chronic inflammation | 134 |
| Factors contributing to chronicity | 136 |
| Maintenance of chronicity | 136 |
| Other cells involved | 139 |
| Tissue damage | 140 |
| Chemical mediators | 140 |
| Essential elements | 140 |
| Granulomatous inflammation | 141 |
| Control of inflammation | 142 |
Part III | Repair of Host Tissues | | 8 | Healing | 149 |
| Resolution vs repair | 149 |
| Regeneration | 150 |
| Fibrous repair | 151 |
| Cell-matrix interaction | 154 |
| Cell-cell interaction | 155 |
| The role cells play in wound healing | 155 |
| What is organization? | 159 |
| Epithelialization | 160 |
| Strength of healing wounds | 161 |
| Remodelling of wounds | 161 |
| Local and systematic factors influencing healing | 165 |
Part IV | Application of Basic Principles | |
9 | Clinical Connections | 171 |
| Inflammation of the tooth pulp (pulpitis) | 172 |
| Inflammatory lesions of the periapical tissues | 185 |
| Acute pyogenic osteomyelitis of the jaws | 196 |
| Chronic osteomyelitis of the jaws | 197 |
| Cellulitis | 197 |
| Periodontal disease | 198 |
| Acquired immunodeficiency syndrome | 203 |
| Answers to Self-Test and Charts | 211 |
Index | | 225 |