Important aims of clinical research include the development of study objectives, research design methodology, and outcome measures. Proper articulation of these goals will lead to the determination of the outcomes of safety, efficacy and/or effectiveness of new dental drugs, biologics, devices, or procedures to improve patient care. This book guides researchers in creating protocols that lead to meaningful outcomes in oral and maxillofacial tissue regeneration. This text is written by a group of eminent investigators with expertise in all facets of clinical research from methodology to clinical protocols. Covered topics include oral and maxillofacial imaging, histomorphometry, examiner calibration, good clinical practice, ridge augmentation, soft and hard tissue grafting, sinus augmentation, and periodontal regeneration protocols. This is an essential reference guide for clinical researchers engaged in research in oral tissue regeneration.


Contents
Part I. General Aspects in Clinical Research
Chapter 01. Research Designs and Hierarchies of Evidence
Chapter 02. Regulatory and Good Clinical Practice Aspects in Clinical Practice
Chapter 03. Ethical Aspects in Clinical Research
Chapter 04. Development of a Clinical Research Protocol
Chapter 05. Management of a Clinical Study
Chapter 06. Authorship and Publication of Clinical Research Findings

Part II. Tools for Preparation, Conduction and Analysis of a Clinical Study
Chapter 07. Endpoints in Oral and Maxillofacial Regeneration Clinical Trials
Chapter 08. Patient Reported Outcome Measures (PROMs) for Implant Dentistry and Oral Tissue Regeneration
Chapter 09. Examiner Standardization and Calibration for Oral and Periodontal Regenerative Studies
Chapter 10. Statistical Analysis for Clinical Studies
Chapter 11. Analytical Methods

Part III. Study Protocols for Specific Indications
Chapter 12. Clinical Research Protocols for Indications in Dental Regeneration


Editors
William Giannobile is the Najjar Endowed Professor of Dentistry and Biomedical Engineering at the School of Dentistry and College of Engineering at the University of Michigan in Ann Arbor. The past-president of the American Academy of Periodontology Foundation, he is currently the Editor-in-Chief of the Journal of Dental Research, the official journal of the International Association of Dental Research.

Niklaus P. Lang is Emeritus Professor of the University of Berne, Switzerland. He is also Honorary Professor at the Universities of Zurich, Hong Kong and University College, UK. Moreover he is the Editor-in-Chief of the Clinical Oral Implants Research journal.

Maurizio S. Tonetti is Executive Director of the European Research Group on periodontology. He owns a private practice limited to Periodontology and Implant Dentistry, in Genova, Italy, and is also Editor-in-Chief of the Journal of Clinical Periodontology.


Contributors
Sofia Aroca • Gustavo Avila-Ortiz • Erika Benavides • Goran Benic • Dieter D. Bosshardt • Pierpaolo Cortellini • MaryAnn Cugini • Gudrun Denke • Nikos Donos • Pablo Galindo-Moreno • William V. Giannobile • Jie Han • Hatice Hasturk • Lisa J. A. Heitz-Mayfield • Jürg Hüsler • Ronald E. Jung • Darnell Kaigler • Alpdogan Kantarci • Niklaus P. Lang • Nikos Mardas • Suzanne Mason • Colman McGrath • Michael K. McGuire • Sven Mühlemann • Ian Needleman • David Nisand • Hector F. Rios • Klaus Peter Rippe • Isabella Rocchietta • Irena Sailer • Giovanni E. Salvi • Mariano Sanz • Anton Sculean • David Schneider • Christina Sim • Massimo Simion • Jeanie Suvan • Daniel S. Thoma • Maurizio S. Tonetti • Fabio Vignoletti • Feng Wang

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